Case report: An atypical spontaneous fracture of the tibial diaphysis following bisphosphonate treatment
Author(s): Magnier M, Gadoin D and Marc Magnier
Abstract: Atypical fractures are a rare, serious adverse effect of long-term bisphosphonate or DENOSUMAB use, typically involving the proximal femur. We present the case of a 53-year-old female with osteoporosis and psoriatic arthritis treated for five years with bisphosphonates and one year with DENOSUMAB. She developed a spontaneous, painful, oblique fracture of the proximal tibia diaphysis following minimal trauma. Radiographic findings and medical history were consistent with an atypical fracture, despite the unusual tibial location. The patient achieved complete healing after eight weeks of non-weight-bearing immobilization, successfully avoiding surgery. This case highlights that atypical fractures can occur in the tibia, urging caution and full assessment for patients on long-term anti-resorptive therapy presenting with unexplained bone pain.
Magnier M, Gadoin D, Marc Magnier. Case report: An atypical spontaneous fracture of the tibial diaphysis following bisphosphonate treatment. Int J Case Rep Orthop 2025;7(2):145-147. DOI: 10.22271/27078345.2025.v7.i2c.276
