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2025, Vol. 7, Issue 2, Part B
Novel pulsatile insulin therapy in foot crush syndrome by using BIONICA-MDI: A case study
Author(s): Pradeep V Mahajan, Harsadbhai D Patel, Anilkumar Daxini, Sarjerao Thorat, Masira Khan and Marilyn Dsouza
Abstract: This case study highlights the remarkable recovery of a 19-year-old male from a severe road traffic accident with right foot crush injury. The patient sustained extensive soft tissue trauma, comminuted fractures, joint dislocations, and was advised to undergo trans-metatarsal or below-knee amputation based on the viability of the skin flap and soft tissues. The patient refused amputation, and choose treatment at StemRx Bioscience Solutions Pvt. Ltd., Navi Mumbai. Over the next four months, the patient was treated with a treatment protocol that involved serial debridement, wound dressings, bone and skin grafting, antibiotics, growth factors, peptides, along with 52 sessions of BIONICA-MDI i.e., pulsatile insulin therapy. This interdisciplinary method focuses on restoring mitochondrial function, improving carbohydrate metabolism, lipid metabolism, enhancing cellular repair, that led to a successful limb salvage, restoring tissue integrity, and avoiding amputation. The case highlights the therapeutic potential of BIONICA-MDI in the management of complex crush foot injury and its role in improving mitochondrial function, reducing inflammation, and accelerating wound healing.
DOI: 10.22271/27078345.2025.v7.i2b.265
Pages: 73-77 | Views: 171 | Downloads: 56
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How to cite this article:
Pradeep V Mahajan, Harsadbhai D Patel, Anilkumar Daxini, Sarjerao Thorat, Masira Khan, Marilyn Dsouza. Novel pulsatile insulin therapy in foot crush syndrome by using BIONICA-MDI: A case study. Int J Case Rep Orthop 2025;7(2):73-77. DOI: 10.22271/27078345.2025.v7.i2b.265
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