Severe carpal tunnel syndrome with long-standing sensorimotor deficits was treated using carpal tunnel release combined with Burkhalter opponensplasty utilizing the extensor indicis proprius tendon. The patient presented with significant functional limitation due to loss of thumb opposition. Following surgery and rehabilitation, she demonstrated restored thumb function, improved grip performance, and complete relief from numbness and tingling. This case highlights the effectiveness of EIP opponensplasty as a dependable reconstructive option in advanced CTS with thenar muscle atrophy, offering functional recovery without compromising index finger movement.